Base Editing
CRISPR-derived editors that chemically convert individual DNA bases without requiring double-strand DNA breaks.
Core metadata
- ID: base_editing
- Era: Modern
- First known date: 2016 (exact)
- Region: Global genome-editing research
- Review status: source_checked
- Maturity: established
Prerequisites
- Programmable Cas9 Nuclease (cas9_programmable_nuclease)
- CRISPR-Cas9 Genome Editing (crispr_gene_editing)
- Protein Engineering (protein_engineering)
Dependents
Fields
Field lanes
- Genome Editing / CRISPR-Cas: Editing Platforms
Node sources
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage (Nature, 2016, primary_paper) • Supports: node, maturity
- Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage (Nature / PubMed Central, 2016, primary_paper) • Supports: node, maturity
- Programmable base editing of A*T to G*C in genomic DNA without DNA cleavage (Nature, 2017, primary_paper) • Supports: node, maturity
Prerequisite edge evidence
Edge/source evidence summary:
- Prerequisite edges: 3
- Average edge confidence: 87%
- Prerequisite sources: 6
- primary_source: 3
| Prerequisite | Type | Confidence | Evidence level | Note | Sources |
|---|---|---|---|---|---|
| CRISPR-Cas9 Genome Editing (crispr_gene_editing) | historical_predecessor | 78% | primary_source | CRISPR-Cas9 genome editing established the programmable Cas9 editing platform that base editing adapted to install base conversions without double-strand DNA cleavage. |
|
| Programmable Cas9 Nuclease (cas9_programmable_nuclease) | required | 92% | primary_source | Cytosine base editors use catalytically impaired Cas9 as the programmable DNA-targeting component fused to a deaminase. |
|
| Protein Engineering (protein_engineering) | required | 90% | primary_source | Base editors are engineered protein fusions, such as deaminase domains joined to catalytically impaired Cas9 variants, making protein engineering a direct component dependency. |
|
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