Ex Vivo CRISPR Cell Therapy
Editing patient or donor cells outside the body, expanding and testing them, then returning them as a therapeutic product.
Core metadata
- ID: ex_vivo_crispr_cell_therapy
- Era: Modern
- First known date: 2016 (decade)
- Region: Global clinical research
- Review status: source_checked
- Maturity: approved
Prerequisites
- Cell Culture (cell_culture)
- CRISPR-Cas9 Genome Editing (crispr_gene_editing)
- CRISPR Off-Target Profiling (crispr_off_target_profiling)
- Viral Vectors (viral_vectors)
Dependents
Fields
Field lanes
- Genome Editing / CRISPR-Cas: Therapeutics
Node sources
- FDA Approves First Gene Therapies to Treat Patients with Sickle Cell Disease (U.S. Food and Drug Administration, 2023, official_agency) • Supports: node, maturity
- Drug delivery systems for CRISPR-based genome editors (Nature Reviews Drug Discovery, 2023, review) • Supports: node, maturity
- CRISPR-Cas9 Gene Editing for Sickle Cell Disease and beta-Thalassemia (New England Journal of Medicine / PubMed, 2021, primary_paper) • Supports: node, maturity
Prerequisite edge evidence
Edge/source evidence summary:
- Prerequisite edges: 4
- Average edge confidence: 74%
- Prerequisite sources: 5
- expert_inference: 3
- primary_source: 1
| Prerequisite | Type | Confidence | Evidence level | Note | Sources |
|---|---|---|---|---|---|
| CRISPR-Cas9 Genome Editing (crispr_gene_editing) | required | 92% | primary_source | Ex vivo CRISPR cell therapy depends on CRISPR-Cas9 genome editing of patient-derived cells before reinfusion. |
|
| Cell Culture (cell_culture) | enabling | 68% | expert_inference | Cell Culture provides a capability that enables this technology without being the only possible path. |
|
| Viral Vectors (viral_vectors) | enabling | 68% | expert_inference | Viral Vectors provides a capability that enables this technology without being the only possible path. |
|
| CRISPR Off-Target Profiling (crispr_off_target_profiling) | enabling | 68% | expert_inference | CRISPR Off-Target Profiling provides a capability that enables this technology without being the only possible path. |
|
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