CRISPR Delivery: AAV, LNP, and RNP
Viral vectors, lipid nanoparticles, and ribonucleoprotein delivery formats used to get genome editors into target cells.
Core metadata
- ID: crispr_delivery_aav_lnp_rnp
- Era: Modern
- First known date: 2015 (decade)
- Region: Global therapeutic research
- Review status: source_checked
- Maturity: established
Prerequisites
- Cell Culture (cell_culture)
- CRISPR-Cas9 Genome Editing (crispr_gene_editing)
- Lipid Nanoparticles (lipid_nanoparticles)
- Viral Vectors (viral_vectors)
Dependents
- Clinical Prime Editing (clinical_prime_editing)
- In Vivo CRISPR Therapeutics (in_vivo_crispr_therapeutics)
- Tissue-Targeted Editor Delivery (tissue_targeted_editor_delivery)
Fields
Field lanes
- Genome Editing / CRISPR-Cas: Delivery
Node sources
- Drug delivery systems for CRISPR-based genome editors (Nature Reviews Drug Discovery, 2023, review) • Supports: node, maturity
- The 60-year evolution of lipid nanoparticles for nucleic acid delivery (Nature Reviews Drug Discovery, 2024, review) • Supports: node, maturity
Prerequisite edge evidence
Edge/source evidence summary:
- Prerequisite edges: 4
- Average edge confidence: 71%
- Prerequisite sources: 4
- expert_inference: 4
| Prerequisite | Type | Confidence | Evidence level | Note | Sources |
|---|---|---|---|---|---|
| CRISPR-Cas9 Genome Editing (crispr_gene_editing) | commercial_or_scaling_dependency | 78% | expert_inference | Delivery methods are scaling and therapeutic-enablement dependencies for CRISPR use in organisms and patients. |
|
| Viral Vectors (viral_vectors) | enabling | 68% | expert_inference | Viral Vectors provides a capability that enables this technology without being the only possible path. |
|
| Lipid Nanoparticles (lipid_nanoparticles) | enabling | 68% | expert_inference | Lipid Nanoparticles provides a capability that enables this technology without being the only possible path. |
|
| Cell Culture (cell_culture) | enabling | 68% | expert_inference | Cell Culture provides a capability that enables this technology without being the only possible path. |
|
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